Code of Life - When Computer Science Meets Genetics Dr.-Ing. Matthieu-P. Schapranow

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Week 1: History of DNA and core components of cells

Back to school: let's test your current biology background. We will start with a concrete real-world use case from medicine to explain core components of human cells, their function, and how they interact.

Welcome to Week 1

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1.1 Discovery of the Human Genome

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1.1 Discovery of the Human Genome

Self-test

1.2 Real-world Use Case: Oncology

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1.2 Real World Use-Case: Oncology

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1.3 Architecture: Components of Cells

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1.3 Architecture: Components of Cells

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1.4 Data Storage: Components of DNA and RNA

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1.4 Data Storage: Components of DNA and RNA

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1.5 Lifecycle Management: Replication

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1.5 Lifecycle Management: Replication

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1.6 Compiling the Code: Transcription and Translation

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1.6 Compiling the Code: Transcription and Translation

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1.7 Bugs: Genetic Changes

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1.7 Bugs: Genetic Changes

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Course Start Survey

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Learning Material

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Weekly Assignment Week 1

Graded Test

Week 2: Processing and analyzing of genetic data

How to turn genetic raw data into meaningful information is the content of this week. Specific data processing steps are required prior to interpreting genetic data. In this week we will address specific algorithms, IT methods, and processes to assess genetic data. Furthermore, you will gain hands-on experience in analyzing selected genetic variants and evaluating their relevance.

Welcome to Week 2

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2.1 Digital Transformation - From DNA and RNA to Data

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2.1 Digital transformation: From DNA and RNA to Data

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2.2 Reconstruct the Genome - Alignment

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2.2 Reconstruct the genome: Alignment

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2.3 Identifying Changes - Variant Calling

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2.3 Identifying Changes - Variant Calling

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2.4 Genetic Annotations

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2.4 Genetic Annotations

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2.5 Reproducible Research - Graphical Pipeline Modeling

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2.5 Reproducible Research - Graphical Pipeline Modeling

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2.6 Reproducible Research - Pipeline Execution

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2.6 Reproducible Research – Pipeline execution

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2.7 Solve the Puzzle

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2.7 Solve the Puzzle

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2.8 Additional Information on the Final Exam

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Learning Material

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Weekly Assignment Week 2

Graded Test

Week 3: Online Q&A and final exams

In this week you will have the chance to discuss any open questions with the teaching team using our online tools. Furthermore, you will have to complete your final exams of the course in this week. We also encourage you to join our "I like, I wish" discussion providing your feedback of the course.

Important information on the final test

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Genome Browser and Medical Knowledge Cockpit

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Genome Browser and Medical Knowledge Cockpit - Accessing the tools

Exercise

Genome Browser and Medical Knowledge Cockpit - Answer the questions

Self-test

Final Test - Part 1 - Finding the Correct Position on the Genome Browser

Graded Exercise

Final Test - Part 2 - Analyzing Genetic Variants with the Genome Browser

Graded Test

Final Test - Part 3 - Tapping into medical research with the Medical Knowledge Cockpit

Graded Test